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KCa1.1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates rat models of rheumatoid arthritis

OBJECTIVE: Fibroblast-like synoviocytes (FLS) participate in joint inflammation and damage during rheumatoid arthritis (RA) and its animal models. The purpose of this study was to define the importance of KCa1.1 (BK, Maxi-K, Slo1, KCNMA1) channel expression and function in FLS and to establish these...

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Foilsithe in:Arthritis Rheumatol
Main Authors: Tanner, Mark R., Hu, Xueyou, Huq, Redwan, Tajhya, Rajeev B., Sun, Liang, Khan, Fatima S., Laragione, Teresina, Horrigan, Frank T., Gulko, Pércio S., Beeton, Christine
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280298/
https://ncbi.nlm.nih.gov/pubmed/25252152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38883
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