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Sarcoplasmic reticulum Ca(2+) release channel ryanodine receptor (RyR(2)) plays a crucial role in aconitine-induced arrhythmias
The present study established a model of RyR(2) knockdown cardiomyocytes and elucidated the role of RyR(2) in aconitine-induced arrhythmia. Cardiomyocytes were obtained from hearts of neonatal Sprague–Dawlay rats. siRNAs were used to down-regulate RyR(2) expression. Reduction of RyR(2) expression wa...
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| Publicat a: | Biochem Pharmacol |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4280015/ https://ncbi.nlm.nih.gov/pubmed/18439986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.02.027 |
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