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Sarcoplasmic reticulum Ca(2+) release channel ryanodine receptor (RyR(2)) plays a crucial role in aconitine-induced arrhythmias

The present study established a model of RyR(2) knockdown cardiomyocytes and elucidated the role of RyR(2) in aconitine-induced arrhythmia. Cardiomyocytes were obtained from hearts of neonatal Sprague–Dawlay rats. siRNAs were used to down-regulate RyR(2) expression. Reduction of RyR(2) expression wa...

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Bibliografiske detaljer
Udgivet i:Biochem Pharmacol
Main Authors: Fu, Min, Li, Ru-Xin, Fan, Li, He, Guo-Wei, Thornburg, Kent L., Wang, Zhao
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280015/
https://ncbi.nlm.nih.gov/pubmed/18439986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.02.027
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