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Effect of severe renal impairment on umeclidinium and umeclidinium/vilanterol pharmacokinetics and safety: a single-blind, nonrandomized study

BACKGROUND: Umeclidinium and vilanterol, long-acting bronchodilators for the treatment of chronic obstructive pulmonary disease, are primarily eliminated via the hepatic route; however, severe renal impairment may adversely affect some elimination pathways other than the kidney. OBJECTIVES: To evalu...

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Bibliografski detalji
Izdano u:Int J Chron Obstruct Pulmon Dis
Glavni autori: Mehta, Rashmi, Hardes, Kelly, Brealey, Noushin, Tombs, Lee, Preece, Andrew, Kelleher, Dennis
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279609/
https://ncbi.nlm.nih.gov/pubmed/25565796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/COPD.S68094
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