Metformin and erlotinib synergize to inhibit basal breast cancer

Basal-like breast cancers (BBCs) are enriched for increased EGFR expression and decreased expression of PTEN. We found that treatment with metformin and erlotinib synergistically induced apoptosis in a subset of BBC cell lines. The drug combination led to enhanced reduction of EGFR, AKT, S6 and 4EBP...

詳細記述

保存先:
書誌詳細
出版年:Oncotarget
主要な著者: Lau, Ying-Ka Ingar, Du, Xing, Reyannavar, Vinayak, Hopkins, Benjamin, Shaw, Jacquelyn, Bessler, Eliana, Thomas, Tiffany, Pires, Maira M., Keniry, Megan, Parsons, Ramon E., Cremers, Serge, Szabolcs, Matthias, Maurer, Matthew A.
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2014
主題:
Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279389/
https://ncbi.nlm.nih.gov/pubmed/25361177
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