Emodin Augments Cisplatin Cytotoxicity in Platinum-Resistant Ovarian Cancer Cells via ROS-Dependent MRP1 Downregulation

The intracellular level of reactive oxygen species (ROS) is closely associated with chemosensitivity of cancer cells. Overexpression of ATP binding cassette transporter MRP1 is correlated with resistance to platinum drugs. In this study, we tested the hypothesis that emodin, a potent ROS generator,...

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Vydáno v:Biomed Res Int
Hlavní autoři: Ma, Jun, Yang, Jie, Wang, Chao, Zhang, Nan, Dong, Ying, Wang, Chengjie, Wang, Yu, Lin, Xinjian
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279181/
https://ncbi.nlm.nih.gov/pubmed/25580427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/107671
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