Emodin Augments Cisplatin Cytotoxicity in Platinum-Resistant Ovarian Cancer Cells via ROS-Dependent MRP1 Downregulation

The intracellular level of reactive oxygen species (ROS) is closely associated with chemosensitivity of cancer cells. Overexpression of ATP binding cassette transporter MRP1 is correlated with resistance to platinum drugs. In this study, we tested the hypothesis that emodin, a potent ROS generator,...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Ma, Jun, Yang, Jie, Wang, Chao, Zhang, Nan, Dong, Ying, Wang, Chengjie, Wang, Yu, Lin, Xinjian
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279181/
https://ncbi.nlm.nih.gov/pubmed/25580427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/107671
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