Emodin Augments Cisplatin Cytotoxicity in Platinum-Resistant Ovarian Cancer Cells via ROS-Dependent MRP1 Downregulation

The intracellular level of reactive oxygen species (ROS) is closely associated with chemosensitivity of cancer cells. Overexpression of ATP binding cassette transporter MRP1 is correlated with resistance to platinum drugs. In this study, we tested the hypothesis that emodin, a potent ROS generator,...

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Bibliographische Detailangaben
Veröffentlicht in:Biomed Res Int
Hauptverfasser: Ma, Jun, Yang, Jie, Wang, Chao, Zhang, Nan, Dong, Ying, Wang, Chengjie, Wang, Yu, Lin, Xinjian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279181/
https://ncbi.nlm.nih.gov/pubmed/25580427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/107671
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