Role of microsatellite instability-low as a diagnostic biomarker of Lynch syndrome in colorectal cancer

Lynch syndrome is the most common Mendelian disorder predisposing to hereditary colorectal cancer. Carriers of MSH6 mutations constitute less than 10% of total cases and present with a weaker clinical phenotype, including low levels of microsatellite instability (MSI-L) in colorectal tumors. The fre...

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Bibliografski detalji
Izdano u:Cancer Genet
Glavni autori: Vilar, Eduardo, Mork, Maureen E., Cuddy, Amanda, Borras, Ester, Bannon, Sarah A., Taggart, Melissa W., Ying, Jun, Broaddus, Russell R., Luthra, Rajyalakshmi, Rodriguez-Bigas, Miguel A., Lynch, Patrick M., You, Y. Nancy
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278939/
https://ncbi.nlm.nih.gov/pubmed/25432668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cancergen.2014.10.002
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