A Cyclic Peptidic Serine Protease Inhibitor: Increasing Affinity by Increasing Peptide Flexibility

Peptides are attracting increasing interest as protease inhibitors. Here, we demonstrate a new inhibitory mechanism and a new type of exosite interactions for a phage-displayed peptide library-derived competitive inhibitor, mupain-1 (CPAYSRYLDC), of the serine protease murine urokinase-type plasmino...

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Publicat a:PLoS One
Autors principals: Zhao, Baoyu, Xu, Peng, Jiang, Longguang, Paaske, Berit, Kromann-Hansen, Tobias, Jensen, Jan K., Sørensen, Hans Peter, Liu, Zhuo, Nielsen, Jakob T., Christensen, Anni, Hosseini, Masood, Sørensen, Kasper K., Nielsen, Niels Christian, Jensen, Knud J., Huang, Mingdong, Andreasen, Peter A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278837/
https://ncbi.nlm.nih.gov/pubmed/25545505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115872
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