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Modest hyperglycemia prevents interstitial dispersion of insulin in skeletal muscle
Insulin injected directly into skeletal muscle diffuses rapidly through the interstitial space to cause glucose uptake, but this is blocked in insulin resistance. As glucotoxicity is associated with endothelial dysfunction, the observed hyperglycemia in diet-induced obese dogs may inhibit insulin ac...
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| Publicado no: | Metabolism |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4277905/ https://ncbi.nlm.nih.gov/pubmed/25468139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2014.10.036 |
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