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Modest hyperglycemia prevents interstitial dispersion of insulin in skeletal muscle

Insulin injected directly into skeletal muscle diffuses rapidly through the interstitial space to cause glucose uptake, but this is blocked in insulin resistance. As glucotoxicity is associated with endothelial dysfunction, the observed hyperglycemia in diet-induced obese dogs may inhibit insulin ac...

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Bibliographic Details
Published in:Metabolism
Main Authors: Kolka, Cathryn M., Castro, Ana Valeria B., Kirkman, Erlinda L., Bergman, Richard N.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277905/
https://ncbi.nlm.nih.gov/pubmed/25468139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2014.10.036
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