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Prolonged Exposure to High and Variable Phenylalanine Levels over the Lifetime Predicts Brain White Matter Integrity in Children with Phenylketonuria

In this study, we retrospectively examined the microstructural white matter integrity of children with early- and continuously-treated PKU (N = 36) in relation to multiple indices of phenylalanine (Phe) control over the lifetime. White matter integrity was assessed using mean diffusivity (MD) from d...

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מידע ביבליוגרפי
הוצא לאור ב:	Mol Genet Metab
Main Authors:	Hood, Anna, Antenor-Dorsey, Jo Ann V., Rutlin, Jerrel, Hershey, Tamara, Shimony, Joshua S., McKinstry, Robert C., Grange, Dorothy K., Christ, Shawn E., Steiner, Robert, White, Desiree A.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2014
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4277899/ https://ncbi.nlm.nih.gov/pubmed/25481106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2014.11.007
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Prolonged Exposure to High and Variable Phenylalanine Levels over the Lifetime Predicts Brain White Matter Integrity in Children with Phenylketonuria

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