Prolonged Exposure to High and Variable Phenylalanine Levels over the Lifetime Predicts Brain White Matter Integrity in Children with Phenylketonuria

In this study, we retrospectively examined the microstructural white matter integrity of children with early- and continuously-treated PKU (N = 36) in relation to multiple indices of phenylalanine (Phe) control over the lifetime. White matter integrity was assessed using mean diffusivity (MD) from d...

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Detalhes bibliográficos
Publicado no:Mol Genet Metab
Main Authors: Hood, Anna, Antenor-Dorsey, Jo Ann V., Rutlin, Jerrel, Hershey, Tamara, Shimony, Joshua S., McKinstry, Robert C., Grange, Dorothy K., Christ, Shawn E., Steiner, Robert, White, Desiree A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277899/
https://ncbi.nlm.nih.gov/pubmed/25481106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2014.11.007
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