Interactions between RNA polymerase and the “core recognition element” counteract pausing

Transcription elongation is interrupted by sequences that inhibit nucleotide addition and cause RNA polymerase (RNAP) to pause. Here, by use of native-elongating-transcript sequencing (NET-seq) and a variant of NET-seq that enables analysis of mutant RNAP derivatives in merodiploid cells (mNET-seq),...

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Udgivet i:Science
Main Authors: Vvedenskaya, Irina O., Vahedian-Movahed, Hanif, Bird, Jeremy G., Knoblauch, Jared G., Goldman, Seth R., Zhang, Yu, Ebright, Richard H., Nickels, Bryce E.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277259/
https://ncbi.nlm.nih.gov/pubmed/24926020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1253458
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