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An Activin A/BMP2 chimera displays bone healing properties superior to those of BMP2

Recombinant Bone Morphogenetic Protein 2 (rhBMP2) has been used clinically to treat bone fractures in human patients. However, the high doses of rhBMP2 required for a therapeutic response can cause undesirable side effects. Here, we demonstrate that a novel Activin A/BMP2 (AB2) chimera, AB204, promo...

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: Yoon, Byung-Hak, Esquivies, Luis, Ahn, Chihoon, Gray, Peter C., Ye, Sang-kyu, Kwiatkowski, Witek, Choe, Senyon
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276739/
https://ncbi.nlm.nih.gov/pubmed/24692083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2238
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