An Activin A/BMP2 chimera, AB215, blocks estrogen signaling via induction of ID proteins in breast cancer cells

BACKGROUND: One in eight women will be affected by breast cancer in her lifetime. Approximately 75% of breast cancers express estrogen receptor alpha (ERα) and/or progesterone receptor and these receptors are markers for tumor dependence on estrogen. Anti-estrogenic drugs such as tamoxifen are commo...

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Detaylı Bibliyografya
Asıl Yazarlar: Jung, Jae Woo, Shim, Sun Young, Lee, Dong Kun, Kwiatkowski, Witek, Choe, Senyon
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122783/
https://ncbi.nlm.nih.gov/pubmed/25070479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-549
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