Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1

Previous studies have shown that activation of mouse MrgC11, a G-protein coupled receptor, by its peptide ligand BAM8-22 can inhibit chronic pain. A large scale screen has been carried out to isolate small molecule allosteric agonists of MrgX1, the human homologue of MrgC11. The goal of this study i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ChemMedChem
Prif Awduron: Wen, Wandong, Wang, Yan, Li, Zhe, Tseng, Pang-Yen, McManus, Owen B., Wu, Meng, Li, Min, Lindsley, Craig W., Dong, Xinzhong, Hopkins, Corey R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276534/
https://ncbi.nlm.nih.gov/pubmed/25209672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402277
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