Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1

Previous studies have shown that activation of mouse MrgC11, a G-protein coupled receptor, by its peptide ligand BAM8-22 can inhibit chronic pain. A large scale screen has been carried out to isolate small molecule allosteric agonists of MrgX1, the human homologue of MrgC11. The goal of this study i...

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Vydáno v:ChemMedChem
Hlavní autoři: Wen, Wandong, Wang, Yan, Li, Zhe, Tseng, Pang-Yen, McManus, Owen B., Wu, Meng, Li, Min, Lindsley, Craig W., Dong, Xinzhong, Hopkins, Corey R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276534/
https://ncbi.nlm.nih.gov/pubmed/25209672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402277
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