HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells

TRAIL has been shown to induce apoptosis in cancer cells, but in some cases certain cancer cells are resistant to this ligand. In this study, we explored the ability of representative HSP90 (heat shock protein 90) inhibitor NVP-AUY922 to overcome TRAIL resistance by increasing apoptosis in colorecta...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Cell Signal
Hoofdauteurs: Lee, Dae-Hee, Sung, Ki Sa, Bartlett, David L., Kwon, Yong Tae, Lee, Yong J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276460/
https://ncbi.nlm.nih.gov/pubmed/25446253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2014.11.013
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items