DNA damage signaling guards against perturbation of cyclin D1 expression triggered by low-dose long-term fractionated radiation

Cyclin D1 expression is precisely controlled during cell-cycle progression. However, repeated exposure to low-dose fractionated radiation (FR) abrogates cell cycle-dependent cyclin D1 degradation by constitutive activation of AKT survival signaling in normal human fibroblasts. The resulting abnormal...

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Detalhes bibliográficos
Publicado no:Oncogenesis
Main Authors: Shimura, T, Kobayashi, J, Komatsu, K, Kunugita, N
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4275562/
https://ncbi.nlm.nih.gov/pubmed/25486524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2014.48
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