Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases.

Monocyte-derived foam cells figure prominently in rupture-prone regions of atherosclerotic plaques. Peripheral blood monocytes in culture can produce certain enzymes that degrade extracellular matrix, known as matrix metalloproteinases (MMPs). Lipid-laden macrophages may thus contribute to weakening...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Galis, Z S, Sukhova, G K, Kranzhöfer, R, Clark, S, Libby, P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42748/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7831299/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.2.402
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