Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair

Heterochromatin is a barrier to DNA repair that correlates strongly with elevated somatic mutation in cancer. CHD class II nucleosome remodeling activity (specifically CHD3.1) retained by KAP-1 increases heterochromatin compaction and impedes DNA double-strand break (DSB) repair requiring Artemis. T...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Cell Biol
Päätekijät: Klement, Karolin, Luijsterburg, Martijn S., Pinder, Jordan B., Cena, Chad S., Del Nero, Victor, Wintersinger, Christopher M., Dellaire, Graham, van Attikum, Haico, Goodarzi, Aaron A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Rockefeller University Press 2014
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274264/
https://ncbi.nlm.nih.gov/pubmed/25533843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201405077
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia