Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair

Heterochromatin is a barrier to DNA repair that correlates strongly with elevated somatic mutation in cancer. CHD class II nucleosome remodeling activity (specifically CHD3.1) retained by KAP-1 increases heterochromatin compaction and impedes DNA double-strand break (DSB) repair requiring Artemis. T...

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Udgivet i:J Cell Biol
Main Authors: Klement, Karolin, Luijsterburg, Martijn S., Pinder, Jordan B., Cena, Chad S., Del Nero, Victor, Wintersinger, Christopher M., Dellaire, Graham, van Attikum, Haico, Goodarzi, Aaron A.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2014
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274264/
https://ncbi.nlm.nih.gov/pubmed/25533843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201405077
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