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Evolution-guided optimization of biosynthetic pathways

Engineering biosynthetic pathways for chemical production requires extensive optimization of the host cellular metabolic machinery. Because it is challenging to specify a priori an optimal design, metabolic engineers often need to construct and evaluate a large number of variants of the pathway. We...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Raman, Srivatsan, Rogers, Jameson K., Taylor, Noah D., Church, George M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273373/
https://ncbi.nlm.nih.gov/pubmed/25453111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409523111
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