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Targeted cancer immunotherapy via combination of designer bispecific antibody and novel gene-engineered T cells
BACKGROUND: Redirection of T lymphocytes against tumor antigens can induce dramatic regression of advanced stage malignancy. The use of bispecific antibodies (BsAbs) that bind both the T-cell receptor (TCR) and a target antigen is one promising approach to T-cell redirection. However, BsAbs indiscri...
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| Publicado no: | J Transl Med |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4272781/ https://ncbi.nlm.nih.gov/pubmed/25496493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0347-2 |
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