Targeted cancer immunotherapy via combination of designer bispecific antibody and novel gene-engineered T cells

BACKGROUND: Redirection of T lymphocytes against tumor antigens can induce dramatic regression of advanced stage malignancy. The use of bispecific antibodies (BsAbs) that bind both the T-cell receptor (TCR) and a target antigen is one promising approach to T-cell redirection. However, BsAbs indiscri...

Full description

Saved in:
Bibliographic Details
Published in:J Transl Med
Main Authors: Urbanska, Katarzyna, Lynn, Rachel C, Stashwick, Caitlin, Thakur, Archana, Lum, Lawrence G, Powell, Daniel J
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272781/
https://ncbi.nlm.nih.gov/pubmed/25496493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0347-2
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items