Targeting and killing of glioblastoma with activated T cells armed with bispecific antibodies

BACKGROUND: Since most glioblastomas express both wild-type EGFR and EGFRvIII as well as HER2/neu, they are excellent targets for activated T cells (ATC) armed with bispecific antibodies (BiAbs) that target EGFR and HER2. METHODS: ATC were generated from PBMC activated for 14 days with anti-CD3 mono...

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Main Authors: Zitron, Ian M, Thakur, Archana, Norkina, Oxana, Barger, Geoffrey R, Lum, Lawrence G, Mittal, Sandeep
格式: Artigo
語言:Inglês
出版: BioMed Central 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3599512/
https://ncbi.nlm.nih.gov/pubmed/23433400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-83
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