Inactivation of a GAL4-Like Transcription Factor Improves Cell Fitness and Product Yield in Glycoengineered Pichia pastoris Strains

With a completely reengineered and humanized glycosylation pathway, glycoengineered Pichia pastoris has emerged as a promising production host for the manufacture of therapeutic glycoproteins. However, the extensive genetic modifications have also negatively affected the overall fitness levels of th...

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Detalhes bibliográficos
Publicado no:Appl Environ Microbiol
Main Authors: Jiang, Bo, Argyros, Rebecca, Bukowski, John, Nelson, Stephanie, Sharkey, Nathan, Kim, Sehoon, Copeland, Victoria, Davidson, Robert C., Chen, Ronghua, Zhuang, Jun, Sethuraman, Natarajan, Stadheim, Terrance A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272754/
https://ncbi.nlm.nih.gov/pubmed/25344235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02619-14
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