Differential hypoglycaemic, anorectic, autonomic and emetic effects of the glucagon-like peptide receptor agonist, exendin-4, in the conscious telemetered ferret

BACKGROUND: Rodents are incapable of emesis and consequently the emetic potential of glucagon-like peptide-1 receptor (GLP-1R) agonists in studies designed to assess a potential blood glucose lowering action of the compound was missed. Therefore, we investigated if the ferret, a carnivore with demon...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Lu, Zengbing, Percie Du Sert, Nathalie, Chan, Sze Wa, Yeung, Chi-Kong, Lin, Ge, Yew, David TW, Andrews, Paul LR, Rudd, John A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272567/
https://ncbi.nlm.nih.gov/pubmed/25491123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0327-6
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