Predicting the emetic liability of novel chemical entities: a comparative study

BACKGROUND AND PURPOSE: Emesis is a multi-system reflex, which is usually investigated using in vivo models. The aim of the study is to compare the response induced by emetic compounds across species and investigate whether dogs, ferrets and rats are all similarly predictive of humans. EXPERIMENTAL...

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Bibliographic Details
Main Authors: du Sert, Nathalie Percie, Holmes, Anthony M, Wallis, Rob, Andrews, Paul LR
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2012
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372835/
https://ncbi.nlm.nih.gov/pubmed/21913900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01669.x
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