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Altered Enzymes in Drug-Resistant Variants of Mammalian Tissue Culture Cells

Two selective procedures are compared in an effort to isolate variants of mouse L cells containing structural gene mutations. Among the resulting variant cloned cell lines are found two types of alterations in the enzyme hypoxanthine phosphoribosyl transferase (EC 2.4.2.8) (1): enzyme with altered k...

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Detalhes bibliográficos
Main Authors: Sharp, J. D., Capecchi, N. E., Capecchi, M. R.
Formato: Artigo
Idioma:Inglês
Publicado em: 1973
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC427189/
https://ncbi.nlm.nih.gov/pubmed/4522295
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