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Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system.

We have targeted the murine thrombomodulin (TM) gene in embryonic stem cells and generated embryos as well as mice with TM deficiency. The heterozygous TM-deficient (TM+/-) mice as compared to wild-type (TM+/+) littermates exhibit 50% reductions in the levels of TM mRNA and TM protein. However, TM+/...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Healy, A M, Rayburn, H B, Rosenberg, R D, Weiler, H
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42718/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7846065/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.3.850
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