Dendritic Cell IL-1α and IL-1β Are Polyubiquitinated and Degraded by the Proteasome

IL-1α and β are key players in the innate immune system. The secretion of these cytokines by dendritic cells (DC) is integral to the development of proinflammatory responses. These cytokines are not secreted via the classical secretory pathway. Instead, 2 independent processes are required; an initi...

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Udgivet i:J Biol Chem
Main Authors: Ainscough, Joseph S., Frank Gerberick, G., Zahedi-Nejad, Maryam, Lopez-Castejon, Gloria, Brough, David, Kimber, Ian, Dearman, Rebecca J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271241/
https://ncbi.nlm.nih.gov/pubmed/25371210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.595686
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