Dendritic Cell IL-1α and IL-1β Are Polyubiquitinated and Degraded by the Proteasome

IL-1α and β are key players in the innate immune system. The secretion of these cytokines by dendritic cells (DC) is integral to the development of proinflammatory responses. These cytokines are not secreted via the classical secretory pathway. Instead, 2 independent processes are required; an initi...

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Опубликовано в: :J Biol Chem
Главные авторы: Ainscough, Joseph S., Frank Gerberick, G., Zahedi-Nejad, Maryam, Lopez-Castejon, Gloria, Brough, David, Kimber, Ian, Dearman, Rebecca J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2014
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271241/
https://ncbi.nlm.nih.gov/pubmed/25371210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.595686
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