The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation

Interleukin-1β (IL-1β) is activated by inflammasome-associated caspase-1 in rare autoinflammatory conditions and in a variety of other inflammatory diseases. Therefore, IL-1β activity must be fine-tuned to enable anti-microbial responses whilst limiting collateral damage. Here, we show that precurso...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Vijayaraj, Swarna L., Feltham, Rebecca, Rashidi, Maryam, Frank, Daniel, Liu, Zhengyang, Simpson, Daniel S., Ebert, Gregor, Vince, Angelina, Herold, Marco J., Kueh, Andrew, Pearson, Jaclyn S., Dagley, Laura F., Murphy, James M., Webb, Andrew I., Lawlor, Kate E., Vince, James E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113568/
https://ncbi.nlm.nih.gov/pubmed/33976225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22979-3
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