Depletion of the Central Metabolite NAD Leads to Oncosis-mediated Cell Death

Depletion of the central metabolite NAD in cells results in broad metabolic defects leading to cell death and is a proposed novel therapeutic strategy in oncology. There is, however, a limited understanding of the underlying mechanisms that connect disruption of this central metabolite with cell dea...

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Vydáno v:J Biol Chem
Hlavní autoři: Del Nagro, Christopher, Xiao, Yang, Rangell, Linda, Reichelt, Mike, O'Brien, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271207/
https://ncbi.nlm.nih.gov/pubmed/25355314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.580159
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