The CLEC-2–podoplanin axis controls fibroblastic reticular cell contractility and lymph node microarchitecture

In lymph nodes, fibroblastic reticular cells (FRCs) form a collagen-based reticular network that supports migratory dendritic cells (DCs) and T cells and transports lymph. A hallmark of FRCs is their propensity to contract collagen, yet this function is poorly understood. Here, we demonstrate that p...

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Détails bibliographiques
Publié dans:Nat Immunol
Auteurs principaux: Astarita, Jillian L., Cremasco, Viviana, Fu, Jianxin, Darnell, Max C., Peck, James R., Nieves-Bonilla, Janice M., Song, Kai, Woodruff, Matthew C., Gogineni, Alvin, Onder, Lucas, Ludewig, Burkhard, Weimer, Robby M., Carroll, Michael C., Mooney, David J., Xia, Lijun, Turley, Shannon J.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270928/
https://ncbi.nlm.nih.gov/pubmed/25347465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3035
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