Loss of microRNA-106b-25 Cluster Promotes Atrial Fibrillation by Enhancing Ryanodine Receptor Type-2 Expression and Calcium Release

BACKGROUND: Enhanced sarcoplasmic reticulum (SR) Ca(2+)-leak via ryanodine receptor type-2 (RyR2) contributes to the pathogenesis of atrial fibrillation (AF). Recent studies have shown that the level of RyR2 protein is elevated in atria of paroxysmal AF (pAF) patients, suggesting that microRNA-media...

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Bibliographic Details
Published in:Circ Arrhythm Electrophysiol
Main Authors: Chiang, David Y., Kongchan, Natee, Beavers, David L., Alsina, Katherina M., Voigt, Niels, Neilson, Joel R., Jakob, Heinz, Martin, James F., Dobrev, Dobromir, Wehrens, Xander H.T., Li, Na
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270890/
https://ncbi.nlm.nih.gov/pubmed/25389315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.114.001973
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