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Loss of microRNA-106b-25 Cluster Promotes Atrial Fibrillation by Enhancing Ryanodine Receptor Type-2 Expression and Calcium Release
BACKGROUND: Enhanced sarcoplasmic reticulum (SR) Ca(2+)-leak via ryanodine receptor type-2 (RyR2) contributes to the pathogenesis of atrial fibrillation (AF). Recent studies have shown that the level of RyR2 protein is elevated in atria of paroxysmal AF (pAF) patients, suggesting that microRNA-media...
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Publicado no: | Circ Arrhythm Electrophysiol |
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Main Authors: | , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4270890/ https://ncbi.nlm.nih.gov/pubmed/25389315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.114.001973 |
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