Thiocoraline activates the Notch pathway in carcinoids and reduces tumor progression in vivo

Carcinoids are slow-growing neuroendocrine tumors (NETs) that are characterized by hormone overproduction; surgery is currently the only option for treatment. Activation of the Notch pathway has previously been shown to have a role in tumor suppression in NETs. The marine-derived thiodepsipeptide th...

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Dettagli Bibliografici
Pubblicato in:Cancer Gene Ther
Autori principali: Wyche, Thomas P., Dammalapati, Ajitha, Cho, Hyunah, Harrison, April D., Kwon, Glen S., Chen, Herbert, Bugni, Tim S., Jaskula-Sztul, Renata
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270822/
https://ncbi.nlm.nih.gov/pubmed/25412645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2014.57
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