Golgi-Located NTPDase1 of Leishmania major Is Required for Lipophosphoglycan Elongation and Normal Lesion Development whereas Secreted NTPDase2 Is Dispensable for Virulence

Parasitic protozoa, such as Leishmania species, are thought to express a number of surface and secreted nucleoside triphosphate diphosphohydrolases (NTPDases) which hydrolyze a broad range of nucleoside tri- and diphosphates. However, the functional significance of NTPDases in parasite virulence is...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Sansom, Fiona M., Ralton, Julie E., Sernee, M. Fleur, Cohen, Alice M., Hooker, David J., Hartland, Elizabeth L., Naderer, Thomas, McConville, Malcolm J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270689/
https://ncbi.nlm.nih.gov/pubmed/25521752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003402
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