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Morphine dependence in single enteric neurons from the mouse colon requires deletion of β‐arrestin2

Chronic administration of morphine results in the development of tolerance to the analgesic effects and to inhibition of upper gastrointestinal motility but not to colonic motility, resulting in persistent constipation. In this study we examined the effect of chronic morphine in myenteric neurons fr...

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Bibliographic Details
Published in:Physiol Rep
Main Authors: Smith, Tricia H., Ngwainmbi, Joy, Hashimoto, Atsushi, Dewey, William L., Akbarali, Hamid I.
Format: Artigo
Language:Inglês
Published: Wiley Periodicals, Inc. 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270231/
https://ncbi.nlm.nih.gov/pubmed/25194025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12140
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