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Opioid receptor desensitization: mechanisms and its link to tolerance
Opioid receptors (OR) are part of the class A of G-protein coupled receptors and the target of the opiates, the most powerful analgesic molecules used in clinic. During a protracted use, a tolerance to analgesic effect develops resulting in a reduction of the effectiveness. So understanding mechanis...
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| Publicado no: | Front Pharmacol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4270172/ https://ncbi.nlm.nih.gov/pubmed/25566076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00280 |
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