A next-generation dual-recombinase system for time and host specific targeting of pancreatic cancer

Genetically engineered mouse models (GEMMs) have dramatically improved our understanding of tumor evolution and therapeutic resistance. However, sequential genetic manipulation of gene expression and targeting of the host is almost impossible using conventional Cre-loxP–based models. We have develop...

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Publicado en:Nat Med
Autores principales: Schönhuber, Nina, Seidler, Barbara, Schuck, Kathleen, Veltkamp, Christian, Schachtler, Christina, Zukowska, Magdalena, Eser, Stefan, Feyerabend, Thorsten B., Paul, Mariel C., Eser, Philipp, Klein, Sabine, Lowy, Andrew M., Banerjee, Ruby, Yang, Fangtang, Lee, Chang-Lung, Moding, Everett J., Kirsch, David G., Scheideler, Angelika, Alessi, Dario R., Varela, Ignacio, Bradley, Allan, Kind, Alexander, Schnieke, Angelika E., Rodewald, Hans-Reimer, Rad, Roland, Schmid, Roland M., Schneider, Günter, Saur, Dieter
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270133/
https://ncbi.nlm.nih.gov/pubmed/25326799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3646
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