A next-generation dual-recombinase system for time and host specific targeting of pancreatic cancer

Genetically engineered mouse models (GEMMs) have dramatically improved our understanding of tumor evolution and therapeutic resistance. However, sequential genetic manipulation of gene expression and targeting of the host is almost impossible using conventional Cre-loxP–based models. We have develop...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Schönhuber, Nina, Seidler, Barbara, Schuck, Kathleen, Veltkamp, Christian, Schachtler, Christina, Zukowska, Magdalena, Eser, Stefan, Feyerabend, Thorsten B., Paul, Mariel C., Eser, Philipp, Klein, Sabine, Lowy, Andrew M., Banerjee, Ruby, Yang, Fangtang, Lee, Chang-Lung, Moding, Everett J., Kirsch, David G., Scheideler, Angelika, Alessi, Dario R., Varela, Ignacio, Bradley, Allan, Kind, Alexander, Schnieke, Angelika E., Rodewald, Hans-Reimer, Rad, Roland, Schmid, Roland M., Schneider, Günter, Saur, Dieter
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270133/
https://ncbi.nlm.nih.gov/pubmed/25326799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3646
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados