A next-generation dual-recombinase system for time and host specific targeting of pancreatic cancer

Genetically engineered mouse models (GEMMs) have dramatically improved our understanding of tumor evolution and therapeutic resistance. However, sequential genetic manipulation of gene expression and targeting of the host is almost impossible using conventional Cre-loxP–based models. We have develop...

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Detaylı Bibliyografya
Yayımlandı:Nat Med
Asıl Yazarlar: Schönhuber, Nina, Seidler, Barbara, Schuck, Kathleen, Veltkamp, Christian, Schachtler, Christina, Zukowska, Magdalena, Eser, Stefan, Feyerabend, Thorsten B., Paul, Mariel C., Eser, Philipp, Klein, Sabine, Lowy, Andrew M., Banerjee, Ruby, Yang, Fangtang, Lee, Chang-Lung, Moding, Everett J., Kirsch, David G., Scheideler, Angelika, Alessi, Dario R., Varela, Ignacio, Bradley, Allan, Kind, Alexander, Schnieke, Angelika E., Rodewald, Hans-Reimer, Rad, Roland, Schmid, Roland M., Schneider, Günter, Saur, Dieter
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270133/
https://ncbi.nlm.nih.gov/pubmed/25326799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3646
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