Genetic Screens Identify a Context-Specific PI3K/p27(Kip1) Node Driving Extrahepatic Biliary Cancer

Biliary tract cancer ranks among the most lethal human malignancies, representing an unmet clinical need. Its abysmal prognosis is tied to an increasing incidence and a fundamental lack of mechanistic knowledge regarding the molecular basis of the disease. Here, we show that the Pdx1-positive extrah...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Falcomatà, Chiara, Bärthel, Stefanie, Ulrich, Angelika, Diersch, Sandra, Veltkamp, Christian, Rad, Lena, Boniolo, Fabio, Solar, Myriam, Steiger, Katja, Seidler, Barbara, Zukowska, Magdalena, Madej, Joanna, Wang, Mingsong, Öllinger, Rupert, Maresch, Roman, Barenboim, Maxim, Eser, Stefan, Tschurtschenthaler, Markus, Mehrabi, Arianeb, Roessler, Stephanie, Goeppert, Benjamin, Kind, Alexander, Schnieke, Angelika, Robles, Maria S., Bradley, Allan, Schmid, Roland M., Schmidt-Supprian, Marc, Reichert, Maximilian, Weichert, Wilko, Sansom, Owen J., Morton, Jennifer P., Rad, Roland, Schneider, Günter, Saur, Dieter
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for Cancer Research 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612573/
https://ncbi.nlm.nih.gov/pubmed/34282029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-21-0209
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