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Translocation between PI(4,5)P(2)-poor and PI(4,5)P(2)-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating
The Orai1-STIM1 current undergoes slow Ca(2+)-dependent inactivation (SCDI) mediated by binding of SARAF to STIM1. Here, we report the use of SCDI by SARAF as a probe of the conformation and microdomain localization of the Orai1-STIM1 complex. We find that interaction of STIM1 with Orai1 C terminus...
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| Publicat a: | Nat Commun |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4270102/ https://ncbi.nlm.nih.gov/pubmed/25517631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6843 |
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