BASIC—ALIMENTARY TRACT: Loss of Parietal Cell Expression of Sonic Hedgehog Induces Hypergastrinemia and Hyperproliferation of Surface Mucous Cells

BACKGROUND & AIMS: Sonic Hedgehog (Shh) is expressed in the adult stomach, but its role as a gastric morphogen is unclear. We sought to identify mechanisms by which Shh might regulate gastric epithelial cell function and differentiation. METHODS: Mice with a parietal cell–specific deletion of Sh...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Xiao, Chang, Ogle, Sally A., Schumacher, Michael A., Orr–Asman, Melissa A., Miller, Marian L., Lertkowit, Nantaporn, Varro, Andrea, Hollande, Frederic, Zavros, Yana
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269486/
https://ncbi.nlm.nih.gov/pubmed/19909751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.11.002
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