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Spartan deficiency causes genomic instability and progeroid phenotypes
Spartan (also known as DVC1 and C1orf124) is a PCNA-interacting protein implicated in translesion synthesis, a DNA damage tolerance process that allows the DNA replication machinery to replicate past nucleotide lesions. However, the physiological relevance of Spartan has not been established. Here w...
Shranjeno v:
| izdano v: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Pub. Group
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4269170/ https://ncbi.nlm.nih.gov/pubmed/25501849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6744 |
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