Spartan deficiency causes genomic instability and progeroid phenotypes

Spartan (also known as DVC1 and C1orf124) is a PCNA-interacting protein implicated in translesion synthesis, a DNA damage tolerance process that allows the DNA replication machinery to replicate past nucleotide lesions. However, the physiological relevance of Spartan has not been established. Here w...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Maskey, Reeja S., Kim, Myoung Shin, Baker, Darren J., Childs, Bennett, Malureanu, Liviu A., Jeganathan, Karthik B., Machida, Yuka, van Deursen, Jan M., Machida, Yuichi J.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Pub. Group 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269170/
https://ncbi.nlm.nih.gov/pubmed/25501849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6744
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