Superior Long-Term Repopulating Capacity of G-CSF+Plerixafor-Mobilized Blood: Implications for Stem Cell Gene Therapy by Studies in the Hbb(th-3) Mouse Model

High numbers of genetically modified hematopoietic stem cells (HSCs) equipped with enhanced engrafting potential are required for successful stem cell gene therapy. By using thalassemia as a model, we investigated the functional properties of hematopoietic stem and progenitor cells (HSPCs) from Hbb(...

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Veröffentlicht in:Hum Gene Ther Methods
Hauptverfasser: Psatha, Nikoleta, Sgouramali, Eleni, Gkountis, Antonios, Siametis, Athanasios, Baliakas, Panayotis, Constantinou, Varnavas, Athanasiou, Evangelia, Arsenakis, Minas, Anagnostopoulos, Achilles, Papayannopoulou, Thalia, Stamatoyannopoulos, George, Yannaki, Evangelia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2014
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268579/
https://ncbi.nlm.nih.gov/pubmed/25333506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2014.005
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