Triosephosphate Isomerase I170V Alters Catalytic Site, Enhances Stability and Induces Pathology in a Drosophila Model of TPI Deficiency

Triosephosphate isomerase (TPI) is a glycolytic enzyme which homodimerizes for full catalytic activity. Mutations of the TPI gene elicit a disease known as TPI Deficiency, a glycolytic enzymopathy noted for its unique severity of neurological symptoms. Evidence suggests that TPI Deficiency pathogene...

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Publicado en:Biochim Biophys Acta
Main Authors: Roland, Bartholomew P., Amrich, Christopher G., Kammerer, Charles J., Stuchul, Kimberly A., Larsen, Samantha B., Rode, Sascha, Aslam, Anoshé A., Heroux, Annie, Wetzel, Ronald, VanDemark, Andrew P., Palladino, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268122/
https://ncbi.nlm.nih.gov/pubmed/25463631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2014.10.010
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