Triosephosphate Isomerase I170V Alters Catalytic Site, Enhances Stability and Induces Pathology in a Drosophila Model of TPI Deficiency

Triosephosphate isomerase (TPI) is a glycolytic enzyme which homodimerizes for full catalytic activity. Mutations of the TPI gene elicit a disease known as TPI Deficiency, a glycolytic enzymopathy noted for its unique severity of neurological symptoms. Evidence suggests that TPI Deficiency pathogene...

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Detaylı Bibliyografya
Yayımlandı:Biochim Biophys Acta
Asıl Yazarlar: Roland, Bartholomew P., Amrich, Christopher G., Kammerer, Charles J., Stuchul, Kimberly A., Larsen, Samantha B., Rode, Sascha, Aslam, Anoshé A., Heroux, Annie, Wetzel, Ronald, VanDemark, Andrew P., Palladino, Michael J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268122/
https://ncbi.nlm.nih.gov/pubmed/25463631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2014.10.010
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